"I knew Trump before, when he was not in politics. I'm not American, but he's a democratically elected president of America, so people have to deal with it," the 83-year-old designer said.
German-born Lagerfeld added that he does not believe the worlds of fashion and politics need to mix the way they often do these days, reported Us magazine.
"Fashion people are fashion, they are not politics," he said.
The iconic designer gave German Chancellor Angela Merkel as an example, saying, "Maybe her clothes are horrible, but she is not in fashion, hmm?"
Melania Trump made her first official White House appearance in a white cashmere Karl Lagerfeld pencil skirt and matching jacket.