Fighting for every single vote at stake, Democratic nominee Clinton and her Republican rival Trump made their last minute forceful argument before the American people with their own vision for the world's largest economy, ending the ugliest presidential campaign in US history.
Clinton, 69, was joined by husband Bill as she addressed a massive rally in Raleigh in the key battle ground state of North Carolina, which was entertained by Lady Gaga.
The two rallies ended around 1 AM (local time), just six hours before opening of the polling booths in the East Coast.
The first ballots were cast in a sleepy hamlet in New Hampshire, traditionally the first in the nation to vote on Election Day, with Clinton winning the contest.
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Clinton registered her first 'win' in the 2016 elections by four votes to two against Trump soon after midnight in the remote Dixville Notch, New Hampshire.
Arizona (11), Florida (29), Nevada (6), Nebraska 2nd Congressional District (1), New Hampshire (4) and North Carolina (15) are key battleground states.
An estimated 200 million people are eligible to cast their votes to elect the country's 45th president along with hundreds of Congressmen and members of state legislatures and local civic bodies.
A record 42 million have already voted using the "early voting" provision of the American electoral system, surpassing the 2012 record when 32.3 million people had voted in advance.
"This election is basically between division and unity in our country. It's between strong and steady leadership or a loose cannon who could put everything at risk. It is between an economy that works for everyone or one that is even more stacked for those at the top," Clinton told a cheering crowd in Raleigh, North Carolina.
"None of us, none of us, want to wake up on Wednesday morning and wish we had done more," she said, which she repeated in her other election rallies including the one in Philadelphia, which was also addressed by US President Barack Obama and First Lady Michelle.