The 40-year-old five-time Academy Award nominee is planning a hush-hush ceremony with Le Gallo at a private location in the LA area, reported the New York Post.
The "Big Eyes" star Adams has been with actor and artist Le Gallo, 40, for 14 years. They became engaged in 2008 and have a daughter, Aviana, who will be five next month.
"Amy and Darren are getting married this weekend in Los Angeles in a ceremony that will be intimate and very genuine. The guest list is being kept very small and she has kept the location very much under wraps," a source said.
Adams and Le Gallo, who live in Beverly Hills, met in an acting class after she starred in 2002's "Catch Me If You Can".