Swift, 26, hit the red carpet at the Staples Center in a leg-baring two-piece by Atelier Versace that included a huge front slit on her skirt.
In response to her glam look, Schumer, 34, posted a bikini photo of herself on the beach with fellow comedian Bridget Everett, and included a cheeky caption.
"Taylor that's not a thigh gap. This is a thigh gap," she wrote.
The superstar's fans were none too pleased with the actress' wisecrack and accused her of skinny shaming.