Michelle Williams, Emily Ratajkowski and Rafe Spall also star in the STX comedy, which marks the directorial debut of screenwriters Abby Kohn and Marc Silverstein, according to The Hollywood Reporter.
The film centers on Schumer as Renee Barrett, an ordinary woman who struggles with feelings of insecurity and inadequacy on a daily basis and finds herself waking from a fall and believing she is suddenly the most beautiful and capable woman on the planet.
Schumer is also producing the project along with Kevin Kane.