The film's script has been written by Abby Kohn and Marc Silverstein. The duo will also direct the movie, reported Variety.
The movie, set to shoot this summer on the East Coast, marks Kohn and Silverstein's directorial debuts.
The plot is being kept under wraps.
The comedienne, who is also a producer on "I Feel Pretty," was last seen in "Trainwreck".
Schumer will also appear alongside Miles Teller in the Universal drama "Thank You for Your Service" from filmmaker Jason Hall.