The 35-year-old actress-comic has dropped out of the Sony movie, according to The Hollywood Reporter.
"Sadly, I'm no longer able to commit to Barbie due to scheduling conflicts. The film has so much promise, and Sony and Mattel have been great partners. I'm bummed, but look forward to seeing Barbie on the big screen," Schumer said.
A Sony spokesperson also said, "We respect and support Amy's decision. We look forward to bringing Barbie to the world and sharing updates on casting and filmmakers soon."