Tied on the eighth spot with just three points with a lone outing thus far in the Grand Chess tour, Anand will have to come out with an impressive performance in the super tournament that also has Magnus Carlsen of Norway starting as the top seed.
The Indian will get five whites and four black games in the 10-player round-robin event being played under classical time control for a total prize pool of USD 300000.
The World Cup will be a knockout event and if Anand finishes in top two, he will get a direct entry in to the next Candidates tournament that decides the challenger to Carlsen in the World Championship.
On paper Carlsen is still the favourite but the reigning world champion has been struggling with his form and has not won any classical tournament for over a year now.
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Fabiano Caruana of USA is another player closing in on Carlsen's domination at 2807 points and the first round might be crucial for the American to bridge the gap as he plays with white against the reigning world champion.
Going by current form, Levon Aronian emerges as the best player in classical chess as the Armenian recently won the Grenke Classic as well as the Norway Chess held in Carlsen's den.
The Grand Chess tour has five events this year compared to four in 2016. The St Louis Rapid and Blitz is a welcome addition after Paris and Luven events that ended recently.
Sinquefield Cup and the London Classic are the only two events that are played under classical chess.
With 25 points in his bag, Carlsen is well ahead of second placed Maxime Vachier-Lagrave in the Grand Chess tour standings.