Andhra still need 64 more runs with five wickets in hand to make MP bat again.
Resuming on 261 for nine, MP added 18 runs to their overnight score to be all out for 279 in their first innings.
In reply, Andhra batsmen had a disastrous outing with Ankit (6/17) getting rid of the top and middle order.
Following on, Andhra faltered yet again, losing five wickets in 48 overs with Ankit (4/65) doing the bulk of the damage this time around as well.
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However, skipper Mohammad Kaif played a responsible knock of 51, while DB Prasanth Kumar (49) and AG Pradeep (36 not out) also chipped in with crucial runs to keep Andhra afloat.
At stumps, NJ Sai Krishna (13 not out) was at the crease along with Pradeep.
Brief scores:
Madhya Pradesh 1st innings: 279
Andhra: 56 (Ankit Sharma 6/17) & 159 for five (f/o) in 48 overs (Mohammad Kaif 51, DB Prasanth Kumar 49; Ankit Sharma 4/65).