Overnight 10 for no loss, Andhra lost Srikar Bharat (25) to pacer Ashish Kumar before romping home with ease.
Andhra are now third on the points table after notching up their second win in four matches. Their other two matches had ended in draws.
This was Jharkhand's first loss of the season after drawing three back-to-back games.
Brief Scores:
Jharkhand: 246 & 104
Andhra Pradesh: 304 & 47/1 in 11 overs (Srikar Bharat 25, Ashish Kumar 1/28).