The USA Network series has been adapted for the US from an original UK sitcom about the lives of paramedics, reported Deadline.
Kindler has been cast as a drug addict known as Bobbie Meds who abuses hospital emergency services.
His episode is scheduled to air in early 2015.
Kindler is a veteran of 'Maron' and 'Everybody Loves Raymond', and also lends his voice to 'Bob's Burgers'.
He is also one of the most frequent guests on 'The Late Show with David Letterman', having made 29 appearances since 2005.
'Sirens' was renewed by the USA Network back in March.