Aniston and Pitt's five-year-old marriage ended in 2005 and it was believed the cause was his closeness to Jolie that developed on the set of their film "Mr and Mrs Smith".
Soon after his split from Aniston, Pitt began dating Jolie.
Now, when the news broke out that Jolie filed for divorce from the 52-year-old actor, social media could not help but imagine how Aniston, who is happily married to actor Justin Theroux, would be feeling right now.
"'Actually, I think I'll have a bagel this morning. With cream cheese. And a margarita.' - Jennifer Aniston, probably," wrote another.
"I just realized that Jennifer Aniston has 0 social media accounts and is living in a kind of bliss none of us can possible imagine," a user posted.
Also, there were the usual gif reactions, culled from a hoard of "Friends" gifs everyone's been building for years.