The 41-year-old Oscar-winning actress, who was reported as being in early talks and was in negotiations to join the cast, never signed a deal to appear in Kenneth Branagh-directed movie, reported Variety.
The makers are now trying to interest a number of other big stars, with Charlize Theron among the actresses being considered.
Branagh will also star as detective Hercule Poirot.
"Blade Runner 2" fame Michael Green is writing the screenplay based on Agatha Christie's novel, with Steve Asbell overseeing the production for Fox Studios.
Sidney Lumet previously made a version of Christie's novel in 1974 with Albert Finney as Poirot.
Branagh will produce the film with Ridley Scott, Simon Kinberg and Mark Gordon.