The autocratic 74-year-old has been the oil-rich country's president since September 1979, making him Africa's second- longest serving leader -- one month short of Equatorial Guinea's Teodoro Obiang Nguema.
His rule has seen the end of civil war and an investment boom, but has also been criticised as secretive and corrupt, with Angola's citizens suffering dire poverty as his family became hugely wealthy.
Dos Santos told a meeting of the ruling MPLA party in Luanda that "the party approved the name of the candidate heading the list in the August elections as (Defence Minister) Joao Manuel Goncalves Lourenco".
Earlier in the year, Dos Santos had said he would step down in 2018.
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The party -- which faces no real political opposition -- recently issued a statement denying reports that Dos Santos was seriously ill.
After constitutional changes in 2010, Angola does not directly elect a president, but the leader of the winning party automatically becomes head of state.
Despite Lourenco being a party loyalist, the end of Dos Santos's regime could open a new chapter for a country largely closed off to the outside world.
"The transition process has now been formalised. This clarity is good for Angola," Alex Vines, director of the Africa Programme at the London-based Chatham House think tank, told AFP.
"Angola has not experienced a change of president since 1979 and so for many Angolans this will be the first time they have witnessed presidential change -- a watershed moment in Angola's modern history."
When Dos Santos became president in 1979 -- following the sudden death from cancer of Angola's liberation president Agostinho Neto -- civil war was already raging between the MPLA government and UNITA rebels, four years after independence from Portugal.