Rose, 44, will portray an attractive woman with terrible taste in men, who has an unfortunate reputation in the conservative town of Salem, reported Variety.
"Assassination Nation" follows four teenage girls in a small suburb who become the focus of unwanted, world-wide media attention after their personal information is leaked by an anonymous hacker. Odessa Young and Hari Nef play the two other teenagers.
Sam Levinson, whose credits include "Another Happy Day" and HBO's upcoming "Wizard of Lies", is directing from his own screenplay.