The 26-year-old singer changes 18 outfits in the May 20 episode of the long-running Fox series, including her infamous meat dress, reported Daily Mirror online.
Gaga, whose real name is Stefani Joanne Angelina Germanotta, arrives in the Simpsons hometown of Springfield aboard the Gaga Express train, which is powered by a giant flame-shooting bustier.
"I play a bit of a slut. The apple doesn't fall far from my artistic tree," said Gaga of her appearance.
The singer is currently on her Born This Way tour.