It is adapted from Kate Manning's period novel 'My Notorious Life', which is based on a true story from the Victorian era, reported The Wrap.
The series follows Axie Muldoon (Paquin), a penniless daughter of immigrants who becomes a successful, yet controversial, midwife and abortionist in New York City.
Paquin, 32, and real-life hubby Stephen Moyer, 45, are reportedly working on the project together.
The duo will apparently executive produce the series through their production company CASM Films, alongside actor-comedian Jack Black, 45.