Ansari would be travelling with a high level delegation to Tashkent between May 21 and 24.
During his interaction with Uzbekistan President Islam Karimov, Ansari would discuss issues like economic reconstruction projects undertaken by New Delhi in the region and cooperation on counter-terrorism in the backdrop of withdrawal of US troops from Afghanistan in 2014.
"Conversations would revolve around economic reconstruction projects and also counter terrorism cooperation," Joint Secretary (Eurasia) in the MEA Ajay Bisaria told reporters ahead of the visit.
Terming terrorism as a "common and pressing concern" for the two countries, he said several radical elements of the Islamic Movement of Uzbekistan, now called Islamic Movement of Turkistan and Hizb-ut Tahrir have found shelter in the region.
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Then Prime Minister P V Narasimha Rao had visited Uzbekistan in 1993 followed by present incumbent Manmohan Singh in 2006.
Karimov had visited India in 1991 as leader of the Communist Party, and later in 1994, 2000, 2005 and 2011 as President of that country.
At least 15 Indian pharmaceutical companies are represented in Uzbekistan where India is also involved in the IT sector. The Jawaharlal Nehru Centre for IT Excellence there is set to be upgraded in the coming days.
India is also setting up a power transmission line which will send Uzbeki power to Afghanistan.
Besides Tashkent, Ansari would also visit the historic cities of Samarkand and Bukhara where he will meet the heads of the regions.