The three-day campaign will cover all the semi-autonomous tribal regions except North and South Waziristan Agencies, Bara sub-district, some areas of Orakzai Agency and three union councils of Frontier Region Bannu.
As a result, some 0.2897 million children will miss the crucial drops.
Arbab Muhammad Arif, Additional Chief Secretary of the tribal areas, administered polio drops to children at the FATA Secretariat to formally inaugurate the campaign in the restive region.
According to official data, a total of 712,985 children will be inoculated during the campaign by 2,638 teams of health workers.
Pakistan is one of only three countries where polio remains endemic.