Syed Saifur Rehman, coordinator of Emergency Polio Cell has asked religious scholars, political parties and people to actively participate in the government's efforts against the crippling virus, the Dawn reported.
"Enough is enough, we have to eradicate this virus from Balochistan," he said.
Meanwhile, security has been beefed up in the volatile region for running of the campaign smoothly.
"Over 6,000 mobile teams, 820 fixed and 334 transit points have been established across the province to administer vaccines," Rehman said.
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"We are launching the campaign amid tight security," he said.
Polio teams and volunteers have repeatedly been targeted by terrorists over the years for supporting anti-polio drive, a major hindrance in government's efforts to eradicate the virus.
In January, at least 15 people, including 12 policemen and a paramilitary soldier, were killed in a suicide bombing targeting polio workers in Quetta. Last month, gunmen shot and wounded a polio worker in Lahore.
Polio is endemic in Pakistan, Afghanistan and Nigeria and the World Health Organisation in May 2014 had imposed travel restrictions on Pakistan.