Prime Minister Baldwin Spencer and his United Progressive Party have led the twin-island country since 2004, but an independent poll conducted by the Barbados-based Caribbean Development Research Services group has given the edge to the Antigua & Barbuda Labor Party led by lawmaker Gaston Browne.
The two main parties and a handful of smaller factions are vying for 17 seats in Parliament.
The Labor Party argues that Spencer's government has mismanaged the economy and failed to create jobs. It has vowed to abolish the personal income tax, construct 500 homes in 500 days and lower corporate taxes.
Nearly 50,000 people are registered to vote in Antigua & Barbuda, which has a population of roughly 90,000.
The islands' tourism-dependent economy was severely hobbled by the global recession and a budget gap worsened after the 2009 collapse of fraudster R Allen Stanford's Antigua-based financial empire. The Texas financier helped fund the government and was the Caribbean country's largest private employer until US authorities accused him of defrauding investors in his offshore bank.