The 52-year-old Hollywood heartthrob has joined the cast of "Los 33", which reveals how the men survived their incredible ordeal while the world watched with bated breath, reported Daily Star.
Film director Patricia Riggen confirmed Banderas will star in the movie.
"Antonio Banderas will be part of our team of actors. We're very happy to have him in the cast. But he's just the first one confirmed. There will be many more," Riggen said.
The miners were imprisoned 2,300ft below ground after a cave-in at the San Jose mine in the Atacama Desert, 500 miles north of the capital Santiago, in August 2010.