The 48-year-old actor played the spoilt brat- turned- ambitious woman Rachel Green in the show which ran from 1994 to 2004.
The actor performed the same hand clap that featured in the beginning of the "Friends" theme song during an appearance on The Ellen DeGeneres Show.
"Y'all should do a Friends reunion. I know people keep asking that. Is it even in the realm of possibility?" Ellen asked.
A photo featuring Aniston and her former colleagues -- Courteney Cox, David Schwimmer, Matthew Perry, Lisa Kudrow and Matt LeBlanc -- appeared in the background.