Aparajith, who batted at no.3, compiled a stroke-filled 105-ball 113 runs, laced with 2 sixes and eight fours, to power South to an imposing 296 for nine.
The Tamil Nadu batsman was well supported by Karun Nair, who made an attacking 74 off 62 balls inclusive of nine hits to the fence as the two revived a stuttering innings with a partnership of 124 in 109 balls for the fourth wicket.
Number-seven batsman Arijit Gupta smashed 5 fixes and as many fours in his 49-ball 66 to keep Central's slender hopes alive till the power play.
South and Karnataka skipper R Vinay Kumar picked up 3 for 8 in 6 overs while little known left-arm spinner Darshan Misal of Goa gave him useful support by grabbing 2 wickets.
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South, who thus avenged the defeat suffered at the hands of Central in the Duleep Trophy final held earlier this month in Delhi, will meet holders and host West Zone in the semi final here on December 1.
Openers Uthappa and Mayank Agarwal, who made an attractive 35, put on 32 runs in testing conditions before both chased wide deliveries and threw away their wickets.
Aparajith, who registered his second ton in the tournament following his innings of 121 against East Zone last season, came to the crease at the fall of opener Uthappa at 32 in the last ball of the 9th over and batted almost right till the end.