Youssef El-Arabi scored in the last minute of extra-time as Olympiakos knocked Arsenal out of the Europa League on Thursday on a night when four former European champions were eliminated.
Ajax, Celtic, Benfica and Porto went out but Manchester United hardly broke sweat after Simon Deli of Brugge conceded a penalty and earned a red card in the 23rd minute at Old Trafford.
Arsenal, last year's losing finalists, had won the first leg of the round of 32 tie 1-0 in Greece.
Defender Pape Abou Cisse cancelled out that advantage when he headed in a corner after 53 minutes.
Arsenal could not break through and were forced to extra time.
Pierre-Emerick Aubameyang put them back in front with a spectacular flying kick. However, in the final minute of extra time, Arsenal cleared an Olympiakos corner but were still disorganised when the ball was swung back into the area.
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The cross found El Arabi free in front of goal for an unchallenged shot.
"Very hard, very tough," said Aubameyang. "Their last-minute goal was unlucky for us." At Old Trafford, Bruno Fernandes gave United the lead with a penalty after Deli's flying save.
Odion Ighalo, making his first start, hit his first goal for the club in the 34th minute.
- Tentative Ajax -
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