After the high of regaining the Ashes in the fourth Test at Trent Bridge, Alastair Cook's side had hoped to celebrate by giving the Australians one last kicking, but instead they were crushed by an innings and 46 runs in four days at The Oval.
It was a downbeat end to a rollercoaster series for England, who at times looked a talented team on the rise and at others surrendered without a fight.
Amid the post-match jubilation after the presentation of the Ashes urn, Bayliss struck a note of warning as he made it clear that the selectors won't be shy of making changes ahead of forthcoming tours against Pakistan and then South Africa.
"Those tours are going to be very difficult. To have sustained success you need good depth," added Bayliss, the first Australian to coach England.
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"I'm not sure of the depth that is there. We have a lot of fast bowling depth, spinners and batters I'm not so sure about.
"It's a chance for players in country cricket to stand up."
England opener Adam Lyth has looked especially out of his depth, having scored just 115 runs in nine innings this Ashes at an average of 12.77.
"There is a selection meeting in a few weeks and I'm sure that will be one of the positions looked at," Bayliss said.
"We all wish him well going forward and I'm sure he will play again at some stage."
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With Lyth unlikely to feature against Pakistan, there is a vacancy to partner Cook at the top of the order.