As well as Cook, England have left out Stuart Broad, Ian Bell, James Anderson and Graeme Swann from their party for the lone one-day international against Ireland and the five-match one-day series with Australia that follows.
However, star batsman Kevin Pietersen has been included in the squad for the Australia series, with fellow Ashes-winning batsmen Joe Root and Jonathan Trott also set to face England's arch-rivals in the one-day format after they too were excused the trip to Dublin.
Meanwhile batsmen Michael Carberry, a key figure with the successful Hampshire county one-day side, and Yorkshire's Gary Ballance will also look to win their first ODI caps.
With Australia's 18-man squad containing just seven players who took part in the Ashes, it is clear both countries are looking ahead to the return Ashes series in Australia starting in November.
England begin their tour with a three-day match against Western Australia starting on October 31, meaning leading players will have little time for a break after a packed home schedule followed back-to-back tours of India and New Zealand.