The train was travelling from the Galician town of Vigo to Portugal when the accident happened near the town of O Porrino.
Authorities in Galicia said two people were killed, but the national rail company Renfe said "several" people died in the train, which was carrying about 60 people.
Spain in 2013 saw one of its worst rail disasters ever when around 80 people were killed and another 144 injured after a train slammed into a concrete wall on the outskirts of Santiago de Compostela.
A pre-trial investigation of the July 24, 2013 crash carried out by a court in Galicia concluded the accident was caused by a lapse in attention by the driver, who was on the telephone at the time of the crash with another rail employee.
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