Upham, 32, was reported missing by her father on October 6, and was last seen leaving her apartment on Sunday in Auburn, Washington, 20 miles south of Seattle, People magazine reported.
"Our officers responded to her apartment where she lives with her parents on Sunday for a suicidal call. When our officers got there, she had already packed up some belongings and left the apartment, so the officers were not able to contact or find her," Commander Steve Stocker said.
"As far as the information we have, she took some things with her, she has a bus pass and even access to some money, and (the case) has been assigned to a detective, but we aren't putting resources (to look for her)," Stocker said.
Police said they have responded to four suicidal calls at Upham's home and this is not the first time Upham has left home, Stocker said.
"We are doing everything within our means to bring our daughter home safe," her family posted on Upham's Facebook page.
Most recently, Upham worked in Jennifer Aniston starrer 'Cake'.