Batting first after winning the toss at the M A Chidambaram Stadium, Australia A were all out for 272 in 47.2 overs.
In reply, the South African A team was bowled out for 164 in only 37.1 overs, with Cameron Boyce (3/48) and Ashton Agar (3/41) picking up three wickets apiece. They were ably supported by pacer Nathan Coulter-Nile, who finished with economical figures of 2/8 from seven overs, as Australia A recorded yet another big win.
Wade smashed his way to 130 off barely 106 balls to lay their foundation for the Australians. The wicketkeeper-batsman was well supported by Peter Handscomb, who made 62-ball 52.
Wade was involved in three fifty partnerships with Joe Burns (11), Chris Lynn (29) and Handscomb during his stay in the middle.
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Sean Abbott made a 24-ball 23 with the help of two fours.
During his stay at the crease, Wade struck nine fours and seven sixes, while Handscomb hit three boundaries.
For the South Africans, captain Dean Elgar was the top-scorer with an 85-ball 64, hitting six boundaries in the process. Khaya Zondo made 47 off 50 deliveries.
Wade said after the win, "Good to win four out of four but it all comes down to the final on Friday and we'll be up for that, ready to go.
"In any one-day game you want to be batting 50 overs, so myself, should probably have batted a little deeper there, Peter Handscomb through to 50 overs.