Video footage provided by the National Police Agency showed the tiny pink pyjama-clad baby gently carried away in a blanket by helmeted rescuers from the rubble of the home.
The rescue of the eight-month-old girl came in the Kumamoto prefectural town of Mashiki, the locale hardest hit by the 6.5-magnitude quake that struck last night.
The girl whose name has not been released, reportedly did not suffer any injuries.
The child's mother, grandfather, grandmother, and older brother were in the living room and kitchen of the home as she slept in another room on the first floor when the quake shook the southern island of Kyushu, the Mainichi Shimbun daily reported.
But a 50-member rescue team managed to pull her safely from the rubble, Kyodo News reported.