Harry Studley remains in a critical condition in Bristol Children's Hospital after being shot on Friday.
Jordan Walters, 24, and Emma Jane Horseman, 23, of Bishport Avenue, have been charged with causing grievous bodily harm.
They have been remanded in custody to appear before Bristol Magistrates' Court tomorrow.
Police were called to a flat in Bishport Avenue in Hartcliffe in the afternoon.
Harry's parents, Amy Allen and Edward Studley, said in a statement issued through the police: "We would like to thank everyone for their continuing support at this time.