Gunmen burst into the house in the small southern town of San Pedro Cacahuatepec and riddled it with gunfire, according to emergency officials.
Three women and a man were also killed in the hail of bullets.
Three children were wounded - ages one, eight and 11.
Local media reports said some of the victims were from the same family.
Some witnesses blamed the attack on a vigilante group called the Union of Towns and Organizations of Guerrero State, or UPOEG.
Guerrero is one of the most violent states in Mexico, caught up in a bloody drug war pitting rival cartels against each other and the army.
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