Leon Bailey scored twice as Bayern Munich crashed 2-1 at home to 10-man Bayer Leverkusen, while RB Leipzig top the Bundesliga after a nervous 3-2 win at bottom side Paderborn.
Hansi Flick lost for the first time in five games as Bayern's interim coach after Jamaica winger Bailey scored first-half goals for Leverkusen.
Mid-table Leverkusen finished with 10 men after defender Jonathan Tah saw a late red card for fouling Philippe Coutinho.
Leipzig's win over Paderborn allowed them to open a two-point lead over Borussia Moenchenglabach.
Elsewhere, Jurgen Klinsmann started his tenure as Hertha Berlin's interim boss with a 2-1 home defeat to 10-man Borussia Dortmund at the sold-out Olympic Stadium.
Flick, put in charge until at least January, had won his first four games with 16 goals scored and zero conceded -- the best start by a coach in Bayern's proud history.
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However, little went right at the Allianz Arena for Bayern, who are fourth and trail Leipzig by three points.
"I didn't flip out after winning four games and I won't now," said Flick.
"We knew Leverkusen were good on the counter and they took their chances mercilessly; we didn't take ours."
- Blank for Lewandowski -
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- 'We deserved more' -
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"We didn't push hard enough."