The gritty Indian youngster gave a terrific fight to a top-50 player and saved four match points before losing 7-6(5) 4-6 3-6, battling hard for two hours and 13 minutes against Britain's number two player.
"Ramkumar has made good progress. It was not easy. He was playing well and I was fighting. I was focusing on my game. It could have gone either way," Bedene said after the match.
Earlier in the evening, seeking a hat-trick of title triumph, Stanislas Wawrinka cruised into the semifinals with a straight-set 6-4 6-4 victory over Guillermo Garcia Lopez of Spain here today.
In the day's other quarterfinal, third seeded Benoit Paire also scored a straight sets win, beating Italian qualifier Thomas Fabbiano 6-4 7-5 after spending 80 minutes on the court.
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Nevertheless, the hero of the day was young Indian, who can hold his head high by putting up a splendid show, courtesy which he has earned crucial 45 ranking points. He beat a top-100 player and a top-200 before braving the challenge of a top-50 player.
Ramkumar's performance is a good news for Indian tennis, which is known to produce quality singles players with monotonic regularity like some of the top nations.
Contending Britain's No 2 player was a task for the Indian, ranked more than 200 places below his fancied opponent.
Ramkumar, though, played fearlessly. He struck powerfully, served well and refused to be intimidated by his rival, who was a runner-up here last year.
Predictably, Bedene stayed strong and was never really troubled by the gutsy Indian. He held his serve quite comfortably even as he made made Ramkumar work hard to earn points.