The big-built Trinidadian came to the crease when the home team had slumped to 68 for three in the ninth over and smashed the ball around in his inimitable style to hit four sixes and six fours to give the innings the boost it needed.
Pollard hammered off-spinner Johan Botha for 22 runs in one over and then carted left-arm slow bowler Ankeet Chavan for a couple of fours and a six before holing out to long on fielder Ajinkya Rahane off the last ball of the 17th over.
The giant West Indian added 96 runs in a blazing fourth wicket stand off just 52 balls with Ambati Rayudu (47 not out in 32 balls) to help MI finish with a tall total on a wicket that helped slow bowlers.
Rayudu was the ideal foil for the big-made Pollard but also played some handsome shots to remain unconquered after striking three sixes and a four as MI surged to the highest total of the IPL season, bettering the 193 made by holders Chennai Super Kings against Deccan Chargers in Hyderabad.
Earlier, MI got off to a decent start through Richard Levi (29) and Rohit Sharma, who looked in sublime form with a well-made 13-ball 21, before both were snapped up by IPL debutant Brad Hogg with beautiful deliveries in successive overs.
Mumbai Indians, put in to bat by Royals skipper Rahul Dravid, made a quiet start before carting left arm spinner Chavan, who opened the attack, for 21 runs in the third over.
T Suman started the mayhem by stepping out to Chavan's first ball in his second over and hoisting it over the straight field for the first six of the game.