The 41-year-old Oscar winner actor would also be the executive producer of the pilot, reported Huffington Post.
The series is based on a story developed by 'Medium' and 'Moonlighting' Emmy nominee Glenn Gordon Caron, who penned the script for the pilot.
'The Middle Man', set in 1960s, explores the unique relationship between Rudy MacAteer, an FBI agent charged with taking down the Italian-American mafia, and his confidential informant, Irish-American gangster Mickey Flood.
The drama will be produced by Fox and Pearl Street Films, with Yebba and Mauro on board to co-executive produce.