Bengal captain Laxmi Ratan Shukla opted to bat after winning the toss and they put up a modest 130 for five on a slow MBB Stadium track.
However, Bengal pacers Sayan Sekhar Mondal (3/13) and Shami Ahmed (2/13) wreaked havoc as Assam were skittled out for 77 in only 16.2 overs.
The victory ensured four points for Bengal from the opening tie.
For the winners, it was Shreevats Goswami who top-scored with 43 off 39 balls that included four boundaries. The pint-sized left-hander however couldn't play his natural game having lost Subhamoy Das (0) to a freak run-out and Debabrata Das retired hurt on six.
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Defending a small target, Bengal bowlers kept Assam under wraps and the fielding was also top notch as they effected three run-outs.
Brief Scores: Bengal 130/5 (Shreevats Goswami 43, Debabrata Das 23) bt Assam 77 in 16.2 overs (Dheeraj Jadhav 19, Sayan Sekhar Mondal 3/13, Shami Ahmed 2/13).