The sixth seeded Indian combination lost 2-6 3-6 in the summit clash of the euro 3,204,745 clay court event.
Such was the domination of the veteran American pair that Indians could not earn even a single break chance.
The Indians lost their serve twice in the opening set and once in the second.
Bhupathi and Bopanna were playing their second final of the season and first together.
Bhupathi had won the Dubai event with Michael Llodra while Bopanna had triumphed at Marseille, France with Colin Fleming.