"Cyprus is poised to become a key player ... Transforming the eastern Mediterranean into a new global hub for natural gas," Biden said on the second day of his visit following a lunch hosted by Cyprus President Nicos Anastasiades.
Anastasiades said the gas deposits, which also have been found in Israeli waters, can offer "an alternative energy corridor leading to increased energy security." He said the discovery could "transform the regional geopolitical landscape and become a force for stability, prosperity and peace."
Biden pledged US government support for efforts to reunifying the island. In 1974, Turkey invaded after a coup by supporters of union with Greece. For the past four decades the island has remained divided into a breakaway Turkish Cypriot north and an internationally recognised Greek Cypriot south.
Turkey, which doesn't recognise Cyprus' sovereignty, has voiced strong opposition to the Cypriot claims to the natural gas fields.
Only Turkey recognises a 1983 Turkish Cypriot declaration of independence and maintains 35,000 troops in the north. Anastasiades said he had "no doubt" that strong US support would help secure Cyprus' rights to exploit its natural resources over Turkish objections.
Analysts say Israel, which already has developed natural gas fields in its waters, may want to utilise Cyprus as a terminus for future pipelines as its own industry expands in the eastern Mediterranean.