He said the target was achievable if both countries made the "right choices".
Biden, however, welcomed relaxation in FDI norms in certain sectors including telecom, defence and insurance and hailed India as a "rising power".
While not setting a deadline for this massive rise in bilateral trade, which is currently driven by software services, Biden, the first US Vice President to visit India in three decades, noted that the two-way trade grew five-fold in the last 13 years to touch USD 100 billion.
Welcoming the recent relaxation in the FDI regime by the government, Biden, however, called for more such measures, saying "we still have a lot of work to do on a wide range of issues, including caps on FDI, inconsistent tax system, barriers to market access, civil nuclear cooperation, bilateral investment treaty and policies protecting innovations."
The US Vice-President also said those economic reforms have helped boost the country's overall exports from USD 20 billion then to over USD 300 billion in FY13.