Written by newcomer Matthew Dressel, it is an ensemble film, which follows the story of a man named Daniel, who attempts to reconnect with his family after his father's death, but soon discovers that his family wants to kill him, said The Hollywood Reporter.
"Most people don't realize how drop dead funny Bill is," said production company Darius Films' VP Development Leah Jaunzems.
"After he read the script, he asked us to push it further - and take every opportunity to make the jokes bigger and more outrageous. That sealed the deal."
Duke, 72, known for his acting roles in films like "Predator" and "Commando", has also directed a slew of movies over the years including "Sister Act 2", "Hoodlum" and, most recently, "Dark Girls".