The 64-year-old actor, who played Dr Peter Venkman in "Ghostbusters" (1984) and "Ghostbusters II" (1989), will appear in director Paul Feig's upcoming installment of the franchise, The Hollywood Reporter said.
Murray has long been resistant to star in a third "Ghostbusters". He told David Letterman earlier this year that his hesitancy stems from "Ghostbusters II" not having been as well-received as the first one.
Feig's film, which is currently shooting, stars Melissa McCarthy, Kristen Wiig, Kate McKinnon, Leslie Jones and Chris Hemsworth. It hits theatres on July 22, 2016.