The 31-year-old Bindra kept his nerve to take the honour in his favourite 10 m air rifle event with a final games record score of 205.3 to bring cheers for the Indian contingent.
The 16-year-old Malaika Goel gave India their first shooting medal with a silver in the women's 10m Air Pistol event while favourite Heena Sidhu fell by the wayside at the Barry Buddon Shooting Centre at Dundee.
India were placed fourth on the medals table with a tally of 3 gold, 4 silver and two bronze behind toppers England (18), Australia (15) and Scotland (10).
It was Bindra's first individual gold medal in the Commonwealth Games. He had won the pairs gold in Manchester (2002), Melbourne (2006) and in front of the home crowd in New Delhi fours years ago.
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In the women's section, Goel shot an aggregate of 197.1 in the finals to finish second and grab her first senior international medal after a close fight for the gold on the opening day of shooting competitions.
The Indian men's hockey team launched their campaign on a sluggish note as they toiled hard to register a 3-1 win over a lowly Wales in their opening Pool A match at the National Hockey Centre.