Bio-molecules in human breast milk stop inflammation

Human breast milk, which provides essential nutrients and antibodies to newborns, also serves as a reservoir for bio-molecules that help resolve inflammation and combat infection, a new study has found.
Breast milk has long been known to play an important role in infant development and the immune system, researchers said.
"Finding a reservoir of these inflammation-resolving molecules at bioactive levels was a big surprise for us," said co-corresponding author Charles Serhan, from the Brigham and Women's Hospital (BWH) in US.
"We've identified some of these molecular signals in other organs and tissue in the human body, but this is the first time we've seen them all in one place," said Serhan.

Using a comprehensive profiling technique, the team was able to uncover a milieu of molecules known as specialised pro-resolving mediators (SPMs) in human breast milk and found that each of these molecules helped resolve inflammation and stimulate immune response in preclinical models.
Certain SPMs have been detected in breast milk before, but this is the first time that such a wide variety of bioactive molecules have been uncovered, including molecules that help clear infections, reduce inflammation, combat pain and heal wounds.

"Human breast milk has many important, protective properties," said co-corresponding author Hildur Arnardottir, who conducted this work while a post-doctoral fellow in the Serhan lab.

"This study extends our understanding of the benefits breast milk provides," said Arnardottir.
The researchers used rigorous detection techniques to look for such signals in human breast milk. The team uncovered a profiling signature consisting of 20 molecules with pro-resolving properties.
They then tested the contributions of samples from breast milk as well as individual molecules in both animal and cellular models of infection, measuring the length of time until resolution.
The team also tested human milk samples from subjects with mastitis, an infection of the breast tissue that causes pain and inflammation.
They found that SPM levels were much lower in milk from mastitis and did not resolve inflammation and infection to the degree that breast milk from non-mastitis samples did.

The team also tested cow's milk and infant formula and did not detect SPM levels.
"Our results suggest a role for SPM in modulating inflammation, infection and stimulating resolution during early immune development, and further reinforce the importance of human breast milk for infants," said Serhan.
The study was published in the journal Mucosal Immunology.