Salah al-Sheikha, dean of Damascus University's faculty of medicine, told the newspaper that before the war Syria recorded around 500,000 births per year.
This year, the number has plummeted to just 200,000, medical sources told Al-Watan, which is close to the government.
The sources attributed the drop to "the reluctance of young people to get married, in addition to emigration... which has had the biggest effect on the number of births dropping to this low level."
Syria's passport control office said a record 5,000 people per day had requested new passports in 2015, compared to 1,000 per day in 2014.
Also Read
The impact of the war on purchasing power may also have discouraged parents from having more children, Al-Watan said.
Around half of Syria's workforce is unemployed and shortages have triggered high inflation.