The cracker - which was kept as a souvenir by James Fenwick, a passenger on board SS Carpathia which helped rescue some of the Titanic's passengers - was stored by him in a Kodak photographic envelope with an original note which read "Pilot biscuit from Titanic lifeboat 1912".
The Spillers and Bakers pilot biscuit - a type of cracker made from flour and water - survived the sinking of the Titanic on April 15.
"It is incredible that this biscuit has survived such a dramatic event - the sinking of the world's largest ocean liner - costing 1,500 lives," he added.
The cracker, which will go under the hammer on October 24, was part of a survival kit stored within one of the ill- fated ocean liner's lifeboats, the Mirror reported.
It is estimated to fetch between 8,000 and 10,000 pounds.
The biscuit will be sold alongside the Fenwick archive - a unique photographic history of the rescue of the survivors from the Titanic.