The ruling alliance turned in its worst-ever performance in the Lok Sabha polls winning just six seats.
BJP won 23, Shiv Sena 18 and ally Swabhimani Paksh one, while Congress managed just two and NCP four, a far cry from the Congress tally of 17 and NCP's 8 in the outgoing Lok Sabha.
As the Opposition gunned for him, demanding his resignation and a snap poll, Chief Minister Prithviraj Chavan said he "fully owned moral responsibility" for the debacle.
Industry minister Narayan Rane, whose son Nilesh failed to retain the coastal Sindhudurg-Ratnagiri seat, resigned from the state cabinet, owing moral responsibility for the defeat. Another Congress minister Nitin Raut also quit after former BJP president Nitin Gadkari won from Nagpur, defeating Vilas Muttemwar of Congress.
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The Aam Aadmi Party, which was the only party to field candidates in all 48 seats, ended with a dud, as did the Raj Thackeray-led MNS, which put up nine candidates.
Senior BJP leader Gopinath Munde retained the Beed seat, defeating NCP minister Suresh Dhas, in one of the keenly watched fights in the state.