The 53-year-old medical professional was nominated to the post by party president Amit Shah in Delhi, BJP said in a release.
Daughter of veteran Congress leader Kumari Ananthan, she becomes the first woman president of Tamil Nadu BJP. Although hailing from a traditionally Congress family, her father being a former TNCC president, Sounderrajan, however, decided to join BJP.
An orator and writer, Sounderrajan started her political career in her student days.
She has earlier unsuccessfully contested Assembly and parliamentary polls.