Dylan wrote his career-changing song in pencil on small sheets of a hotel stationery in 1965. The manuscript features corrections and revisions of the lyrics, as well as doodles in the margin and notes about the musician's life, reported Contactmusic.
The lyrics will be sold by a Californian friend and business associate of the singer, who bought it from him three years ago. Accompanying the manuscript is a letter from Dylan's lawyer verifying its authenticity.
Experts at Sotheby's, the agency who will auction the manuscript, has described it as "the most significant piece of rock material to appear at auction."